Catheterization of the gallbladder: A novel mouse model of severe acute cholangitis

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Catheterization of the gallbladder: A novel mouse model of severe acute cholangitis

AIM To establish a severe acute cholangitis (SAC) model in mice. METHODS Cholecystic catheterization was performed under the condition of bile duct ligation (BDL). Trans-cholecystic injection of lipopolysaccharide (LPS) was defined as the SAC animal model. Sham operation group, intraperitoneal injection of LPS without BDL group, intraperitoneal injection of LPS with BDL group and trans-cholec...

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Establishment of a novel rat model of severe acute cholangitis.

OBJECTIVES This study aimed to establish a novel non-binding, reversible rat model of acute cholangitis of the severe type (ACST). MATERIALS AND METHODS Twenty-six rats were randomly divided into the sham-operated group (n=13) and the ACST group (n=13). All rats were intubated with a modified catheter through the external jugular vein. The ACST model was established by ligation of the distal ...

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ژورنال

عنوان ژورنال: World Journal of Gastroenterology

سال: 2017

ISSN: 1007-9327

DOI: 10.3748/wjg.v23.i10.1771